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Have you setup photoshop properly to suit your needs. ie in performance settings have you increased the ram which your allowing photoshop to use if you have 16gb of ram then increase it to 12gb which photoshop can run at if you have 8gb then try setting it to 6gb never set it to use 100% of your available ram as it will cause your computer to freeze.

if your still having problems then maybe go down the approach of resizing the image while working on it and using a specific method of resizing it back up when ready to print. I am not saying this is the best idea but you may get away with some good scaling once again it depends on the type of image on what method you use or if you use a 3rd party plugin for it. I must stress it is a lot easier to downsize an image and retain quality but a lot harder to blow up the image and keep the desired quality.