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I saw this reply from"Steve" in another thread.thought it would be a good thread for search purposes

How to reset Photoshop preferences (In Windows):

First, hold down all three Ctrl+Alt+Shift buttons

Now "while keeping those button held," simply open Photoshop or a file that opens with Photoshop

As Photoshop loads, you should get a prompt asking if you would like to "delete the Photoshop settings file", Click yes

You should now have a fresh slate with all of the settings returned to their default.

Thanks Steve!

Can't forget Gaussian  he says

On a Mac, hold Command+Option+Shift while starting Photoshop to delete the preferences.